Antimetastatic therapy targeting aberrant sialylation profiles in cancer cells
نویسندگان
چکیده
منابع مشابه
Targeting aberrant sialylation in cancer cells using a fluorinated sialic acid analog impairs adhesion, migration, and in vivo tumor growth.
Cancer cells decorate their surface with a dense layer of sialylated glycans by upregulating the expression of sialyltransferases and other glycogenes. Although sialic acids play a vital role in many biologic processes, hypersialylation in particular has been shown to contribute to cancer cell progression and metastasis. Accordingly, selective strategies to interfere with sialic acid synthesis ...
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ژورنال
عنوان ژورنال: Drugs and Therapy Studies
سال: 2011
ISSN: 2038-9507,2038-9493
DOI: 10.4081/dts.2011.e12